解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Lassa hemorrhagic fever (LHF) is a neglected tropical disease with significant impact on the health care system, society, and economy of Western and Central African nations where it is endemic. With a high rate of infection that may lead to morbidity and mortality, understanding how the virus interacts with ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-306
更新日期:2010-11-09 00:00:00
abstract:BACKGROUND:The recent 2009 (H1N1) influenza A pandemic saw a rapid spread of the virus to essentially all parts of the world. In the course of its evolution, the virus acquired many mutations, some of which have been investigated in the context of increased severity due to high occurrences in fatal cases. For example, ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-297
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Tomato leaf curl virus (ToLCV), a constituent of the genus Begomovirus, infects tomato and other plants with a hallmark disease symptom of upward leaf curling. Since microRNAs (miRs) are known to control plants developmental processes, we evaluated the roles of miRNAs in Tomato leaf curl New Delhi virus (ToL...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-281
更新日期:2010-10-25 00:00:00
abstract:BACKGROUND:Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. RESULTS:In this study, the genetic and antigenic properties of these strains were analyzed and the genetic div...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-277
更新日期:2010-10-20 00:00:00
abstract::An 80-year-old man with no history of an immune-compromising disorder was diagnosed with progressive multifocal leukoencephalopathy (PML). He presented with dysphagia and left-sided weakness; magnetic resonance imaging demonstrated marked signal abnormality in the subcortical white matter of the left frontal lobe and ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-256
更新日期:2010-09-28 00:00:00
abstract:BACKGROUND:Oral malignancy is a major global health problem. Besides the main risk factors of tobacco, smoking and alcohol, infection by human papillomavirus (HPV) and genetic alterations are likely to play an important role in these lesions. The purpose of this study was to compare the efficacy of HC-II assay and PCR ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-253
更新日期:2010-09-23 00:00:00
abstract::The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus were carried out. No recombination signal was found. With the previo...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-227
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:The Unique Long 26 (UL26) and UL26.5 proteins of herpes simplex virus are known to function during the assembly of the viruses. However, for duck enteritis virus (DEV), which is an unassigned member of the family Herpesviridae, little information is available about the function of the two proteins. In this s...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-223
更新日期:2010-09-13 00:00:00
abstract:BACKGROUND:Infection with hepatitis B virus (HBV) is major public health concern. The limitations of available antiviral drugs require development of novel approaches to inhibit HBV replication. This study was conducted to identify functional elements and new siRNA target sites within the highly conserved regions of th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-216
更新日期:2010-09-08 00:00:00
abstract:BACKGROUND:Chronic viral hepatitis B remains a global public health concern. Currently, several drugs, such as lamivudine and telbivudine, are recommended for treatment of patients with chronic hepatitis B. However, there are no conclusive results on the comparison of the efficacy of lamivudine (LAM) and telbivudine (L...
journal_title:Virology journal
pub_type: 杂志文章,meta分析,评审
doi:10.1186/1743-422X-7-211
更新日期:2010-09-03 00:00:00
abstract::Six major Hepatitis C virus (HCV) genotypes and hundreds of subtypes have been identified globally. All these genotypes are generally studied for epidemiology, their vaccine development and clinical management. This article comments the frequency distribution of various HCV genotypes circulate in different areas/distr...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-203
更新日期:2010-08-26 00:00:00
abstract:BACKGROUND:Uukuniemi virus (UUKV) belongs to the Phlebovirus genus in the family Bunyaviridae. As a non-pathogenic virus for humans UUKV has served as a safe model bunyavirus in a number of studies addressing fundamental questions such as organization and regulation of viral genes, genome replication, structure and ass...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-187
更新日期:2010-08-10 00:00:00
abstract:BACKGROUND:Newcastle disease (ND), caused by Newcastle disease virus (NDV), is a highly contagious disease of birds and has been one of the major causes of economic losses in the poultry industry. Despite routine vaccination programs, sporadic cases have occasionally occurred in the country and remain a constant threat...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-183
更新日期:2010-08-08 00:00:00
abstract:OBJECTIVE:To determine HIV-1 RNA load during the third trimester of pregnancy and evaluate its effect on in utero and intra-partum/postpartum transmissions in a breastfeeding population. DESIGN:A nested case-control study within a PMTCT cohort of antiretroviral therapy naive pregnant women and their infants. METHODS:...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-176
更新日期:2010-08-02 00:00:00
abstract:BACKGROUND:Human adenoviruses (Ads) have substantial potential for clinical applications in cancer patients. Conditionally replicating adenoviruses (CRAds) include oncolytic adenoviruses in which expression of the immediate early viral transactivator protein E1A is controlled by a cancer cell-selective promoter. To enh...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-175
更新日期:2010-07-29 00:00:00
abstract::From April 2007 to March 2008, cloacal swabs were obtained from 246 casualty raptors recovered by various wildlife rehabilitation centers in the United States. The swabs were placed in a virus transport medium and transported to the laboratory on ice packs. At the laboratory, the samples were pooled with each pool con...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-174
更新日期:2010-07-28 00:00:00
abstract::Porcine Hokovirus (PHoV) was recently discovered in Hong Kong. This new Parvovirus of pigs is closely related to the human Parvoviruses 4 and 5 (PARV4/5) and bovine Hokovirus (BHoV). So far, nothing is known about the presence and prevalence of PHoV in regions of the world other than Hong Kong. A study was initiated t...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-171
更新日期:2010-07-25 00:00:00
abstract:BACKGROUND:Previously, we have reported the isolation and molecular characterization of human Hepatitis C virus genotype 1 (HCV-1) from infected patients. We are now reporting an analysis of HCV obtained from patients infected with HCV genotype 3 (HCV-3) as diagnosed by clinical laboratories. RESULTS:HCV was cultured ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-155
更新日期:2010-07-13 00:00:00
abstract:BACKGROUND:Since its first appearance in the USA in 1999, West Nile virus (WNV) has spread in the Western hemisphere and continues to represent an important public health concern. In the absence of effective treatment, there is a medical need for the development of a safe and efficient vaccine. Live attenuated WNV vacc...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-146
更新日期:2010-07-06 00:00:00
abstract:UNLABELLED:In the study, a method called "hardening in liquid phase" for preparing chitosan granules with glutaraldehyde as crosslinker and Tween 80 as surfactant and paraffin liquid as dispersant was established. The chitosan granules were light yellow and insoluble in water or oil, but they swelled in acid solution a...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-125
更新日期:2010-06-12 00:00:00
abstract:BACKGROUND:Papillomaviruses (PVs) establish a persistent infection in the proliferating basal cells of the epithelium. The viral genome is replicated and maintained as a low-copy nuclear plasmid in basal keratinocytes. Bovine and human papillomaviruses (BPV and HPV) are known to utilize two viral proteins; E1, a DNA he...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-123
更新日期:2010-06-10 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection is a major public health problem with more than 170 million cases of chronic infections worldwide. There is no protective vaccine currently available for HCV, therefore the development of novel strategy to prevent chronic infection is important. We reported earlier that a re...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-118
更新日期:2010-06-07 00:00:00
abstract:BACKGROUND:The threat of recurring influenza pandemics caused by new viral strains and the occurrence of escape mutants necessitate the search for potent therapeutic targets. The dependence of viruses on cellular factors provides a weak-spot in the viral multiplication strategy and a means to interfere with viral multi...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-108
更新日期:2010-05-26 00:00:00
abstract::Avian influenza virus H9N2 isolates cause a mild influenza-like illness in humans. However, the pathogenesis of the H9N2 subtypes in human remains to be investigated. Using a human alveolar epithelial cell line A549 as host, we found that A/Quail/Hong Kong/G1/97 (H9N2/G1), which shares 6 viral "internal genes" with th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-71
更新日期:2010-03-25 00:00:00
abstract::The suitability of V4 vaccine coated on cracked local grain (maize) and its husks and used for oral vaccination of chickens was assessed. Seventy-two (72) birds aged three (3) weeks and above were divided into six groups of twelve (12) birds per group. The birds were bled to determine their prevaccination HI antibody ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-67
更新日期:2010-03-23 00:00:00
abstract:BACKGROUND:Some genotypes of human papillomaviruses can infect the genital tract and they are important infectious agents which their oncogenicity is regardable. Thus the aim of this study was to determine the prevalence of various genital human papillomaviruses (HPV) among women being subjected to routine pap smear te...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-65
更新日期:2010-03-22 00:00:00
abstract:BACKGROUND:Human herpes virus 8 (HHV-8) is the etiologic agent associated with development of classical, AIDS-related, iatrogenic, and endemic Kaposi's sarcoma (KS). Several studies provide strong evidence that HHV-8 can be transmitted by blood transfusion. We evaluated the seroprevalence and potential risk factors of ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-62
更新日期:2010-03-17 00:00:00
abstract::Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain c...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-54
更新日期:2010-03-06 00:00:00
abstract::Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding th...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-52
更新日期:2010-03-04 00:00:00
abstract:BACKGROUND:The Hepatitis B Virus X protein (HBx) plays a major role in hepatocellular carcinoma (HCC) development, however, its contribution to tumor invasion and metastasis has not been established so far. Heat shock protein 90 alpha (HSP90alpha) isoform is an ATP-dependent molecular chaperone that maintains the activ...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-45
更新日期:2010-02-20 00:00:00
abstract:BACKGROUND:Viruses included in the family Iridoviridae are large, icosahedral, dsDNA viruses that are subdivided into 5 genera. Frog virus 3 (FV3) is the type species of the genus Ranavirus and the best studied iridovirus at the molecular level. Typically, antibodies directed against a virus act to neutralize the virus...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-41
更新日期:2010-02-18 00:00:00
abstract:BACKGROUND:Throughout the history of human influenza pandemics, pigs have been considered the most likely "mixing vessel" for reassortment between human and avian influenza viruses (AIVs). However, the replication efficiencies of influenza viruses from various hosts, as well as the expression of sialic acid (Sia) recep...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-38
更新日期:2010-02-16 00:00:00
abstract:BACKGROUND:Viral delivery remains one of the most commonly used techniques today in the field of gene therapy. However, one of the remaining hurdles is the off-targeting effect of viral delivery. To overcome this obstacle, we recently developed a method to incorporate an antibody and a fusogenic molecule (FM) as two di...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-35
更新日期:2010-02-11 00:00:00
abstract::The TAR RNA of HIV was engineered as an siRNA delivery vehicle to develop a combinatorial therapeutic approach. The TAR backbone was found to be a versatile backbone for expressing siRNAs. Upon expression in human cells, pronounced and specific inhibition of reporter gene expression was observed with TARmiR. The resul...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-33
更新日期:2010-02-10 00:00:00
abstract:BACKGROUND:Human astroviruses (HAstVs) are one of the important causes of acute gastroenteritis in children. Currently, eight HAstV genotypes have been identified and all but two (HAstV-6 and HAstV-7) have been fully sequenced. We here sequenced and analyzed the complete genome of a HAstV-6 strain (192-BJ07), which was...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-29
更新日期:2010-02-08 00:00:00
abstract:BACKGROUND:Myxoma virus is a member of the Poxviridae and causes disease in European rabbits. Laboratory confirmation of the clinical disease, which occurs in the autumn of most years in Denmark, has been achieved previously using antigen ELISA and electron microscopy. RESULTS:An unusually large number of clinically s...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-7
更新日期:2010-01-16 00:00:00
abstract::We undertook one of the most detailed studies on the distribution of alpha2,3 sialic acid (SA)-galactose (gal) (avian type) and alpha2,6SA-gal (human type) receptors on different tissues of chickens, ducks and turkeys of varying age groups. On the tracheal epithelium, all 3 bird species expressed strong positive stain...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-5
更新日期:2010-01-12 00:00:00
abstract:BACKGROUND:Classical swine fever (CSF) caused by virulent strains of Classical swine fever virus (CSFV) is a haemorrhagic disease of pigs, characterized by disseminated intravascular coagulation, thrombocytopoenia and immunosuppression, and the swine endothelial vascular cell is one of the CSFV target cells. In this re...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-4
更新日期:2010-01-11 00:00:00
abstract:BACKGROUND:SEN virus is a blood-borne, circular ssDNA virus and possessing nine genotypes (A to I). Among nine genotypes, SENV-D and SENV-H genotypes have the strong link with patients with unknown (none-A to E) hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassem...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-7-1
更新日期:2010-01-02 00:00:00
abstract:BACKGROUND:For years, the understanding of the pathogenetic mechanisms that underlie honey bee viral diseases has been severely hindered because of the lack of a cell culture system for virus propagation. As a result, it is very imperative to develop new methods that would permit the in vitro pathogenesis study of hone...
journal_title:Virology journal
pub_type: 杂志文章
doi:10.1186/1743-422X-6-221
更新日期:2009-12-11 00:00:00